Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

New

Anti-FOLR1 (Mirvetuximab), Humanized Antibody

The biosimilar is a humanized antibody that targets Folate receptor 1 (FOLR1)
Catalog #: A2271
$465.00

Product Details

Cat # +Size A2271-100
Size 100 μg
Antibody Target FOLR1
Alternate Name FBP, FOLR, NCFTD, FRalpha, FOLR1, Folate Receptor 1 (Adult), KB Cells FBP, FR-Alpha, FRα
Host Recombinant
Antibody Type Monoclonal
Isotype IgG1, kappa
Immunogen Human FOLR1
Accession # DB16235
Gene ID 2348
Appearance Colorless liquid
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a recombinant antibody to Mirvetuximab without the drug conjugation. The original antibody-drug conjugate (Mirvetuximab soravtansine) consists of an anti-FOLR1 humanized antibody conjugated to DM4, an anti-tumor chemical derivative of maytansine via a disulfide-containing cleavable sulfo-SPDB linker. Upon interaction and internalization by FOLR1 expressing tumor cells, the DM4 is detached from the antibody due to proteolytic cleavage. The DM4 then inhibits polymerization of the tubulin and assembly of the microtubules, thus resulting in cell cycle arrest and apoptosis. The original antibody-drug conjugate is used as an investigational agent to treat a variety of cancers such as ovarian, endometrial, fallopian tube, epithelial ovarian, and primary peritoneal cancer


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.