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Anti-FGF21 Antibody (Clone# ARC0865)

Rabbit monoclonal antibody that detects the expression of FGF21 in human, mouse, and rat samples
Catalog #: A2237
$360.00

Product Details

Cat # +Size A2237-100
Size 100 μl
Antibody Target FGF21
Alternate Name Fibroblast Growth Factor 21, FGF-21, FGF21, FGF 21
Host Rabbit
Antibody Type Monoclonal
Isotype IgG
Immunogen Synthetic peptide derived from human FGF21
Accession # Q9NSA1
Gene ID 26291
Appearance Colorless liquid
Formulation In PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH 7.3
Purification Affinity purified
Species Reactivity Human, Mouse, Rat
Application Immunohistochemistry (IHC), Western Blotting
Application & Usage WB 1:500 - 1:2000, IHC 1:50 - 1:200
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Fibroblast growth factor 21 (FGF21) is a pleiotropic hormone that belongs to the fibroblast growth factor family that has multifaceted roles in biological processes such as angiogenesis, metabolism, embryonic development, and tumor growth and invasion. FGF21 is expressed in multiple tissues such as the liver, adipose tissue, pancreas, brain, and gastrointestinal tract. FGF21 is known as a major regulator of glucose and lipid metabolism. Under nutritional stress conditions (fasting, caloric restriction, ketogenic diets), FGF21 stimulates the production of glucose in the liver via gluconeogenesis. In the adipose tissue, it increases the uptake of glucose by stimulating the expression of GLUT1. FGF21 promotes weight loss without decreasing the intake of food, decreases the fat content in the liver, and reduces triglyceride and glucose concentrations in the blood plasma. Due to its beneficial role in energy homeostasis and metabolism, FGF21 has been proposed as a therapeutic target for metabolic disorders.


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