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Anti-F9/F10, Humanized Antibody

Biosimilar to Emicizumab, monoclonal antibody that targets F9/F10
Catalog #: A2250
$460.00

Product Details

Cat # +Size A2250-100
Size 100 μg
Antibody Target F9/F10
Alternate Name FIX, P19, PTC, HEMB, THPH8, F9 p22, F9, FX, FXA, F10
Host Recombinant
Antibody Type Monoclonal
Isotype IgG4, kappa
Immunogen Human Factor 9/Factor 10
Accession # DB13923
Gene ID 2158/2159
Appearance Colorless liquid
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a bispecific humanized monoclonal antibody that specifically binds to both Factor IXa and Factor X. Under normal conditions, the presence of thrombin or other coagulation factors causes dissociation of Factor VIII from vWF and enables the formation of activated Factor VIIIa. Activated Factor VIIIa then binds to activated Factor IXa on the phospholipid surface of platelet cells. This complex formation favors the binding of Factor IXa to Factor X and its subsequent conversion to Factor Xa, which later promotes the coagulation process. Hemophilic patients are deficient in Factor VIII/VIIIa and hence have a dysfunctional process of coagulation.


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