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Anti-ERCC1 Antibody

Affinity purified rabbit polyclonal antibody to ERCC1
Catalog #: A1937
$325.00

Product Details

Cat # +Size A1937-100
Size 100 µl
Antibody Target ERCC1
Alternate Name ERCC1; COFS4; RAD10; UV20; DNA excision repair protein ERCC-1
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Immunogen Recombinant fusion protein corresponding to aa 1-323 of human ERCC1 (NP_973730.1)
Accession # P07992
Gene ID 2067
Appearance Liquid
Formulation In PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification Affinity purified
Species Reactivity Mouse, Human
Application Immunofluorescence (IF), Western Blotting
Application & Usage IF 1:50 - 1:200, WB 1:500 - 1:2000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.


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