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Anti-EHMT2 Antibody

Polyclonal antibody to detect endogenous levels of EHMT2 in human, mouse and rat samples
Catalog #: A1676

In stock

$395.00

Product Details

Cat # +Size A1676-100
Size 100 µl
Antibody Target EHMT2
Alternate Name BAT8; C6orf30; G9A; KMT1C; NG36; Histone-lysine N-methyltransferase EHMT2; Euchromatic histone-lysine N-methyltransferase 2; HLA-B-associated transcript 8; Histone H3-K9 methyltransferase 3; H3-K9-HMTase 3; Lysine N-methyltransferase 1C; Protein G9a
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen A synthesized peptide derived from human EHMT2
Accession # Q96KQ7
Gene ID 10919
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol
Purification Affinity purified
Species Reactivity Human, Mouse, Rat
Application WB, IHC
Positive Control WB: HeLa cell lystae, IHC: Mouse liver tissue
Application & Usage WB 1:500-1:2000, IHC 1:50-1:200
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

G9a, also known as Euchromatic histone-lysine N-methyltransferase 2 (EHMT2), is a member of a family of histone lysine methyltransferases, each of which contains a conserved catalytic SET domain originally identified in Drosophila Su[var]3-9, Enhancer of zeste, and Trithorax proteins. Recombinant G9a can mono-, di- and tri-methylate histone H3 on Lys9 and Lys27 in vitro. However, in vivo G9a forms a complex with GLP, a G9a-related histone methyltransferase, and together these proteins function as the major euchromatic histone H3 Lys9 mono- and di-methyltransferases, creating transcriptionally repressive marks that facilitate gene silencing. G9a methylates itself on Lys165, a modification that regulates the association of HP1 repressor proteins with the G9a/GLP complex.


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