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Anti-EGFR (Panitumumab), Humanized Antibody

Monoclonal human IgG2k antibody against human EGFR
Catalog #: A1050
$415.00

Product Details

Cat # +Size A1050-100
Size 100 µg
Antibody Target EGFR
Alternate Name Vectibix
Host Recombinant
Antibody Type Monoclonal
Isotype Human IgG2k
Immunogen EGFR
Accession # Q147T7
Gene ID 1956
Appearance Colourless liquid
Concentration 1 mg/ml
Formulation 100 μg of purified monoclonal anti-EGFR human IgG1antibody in phosphate buffered saline, pH 7.4.
Purification Selected human IgG2k was expressed in a human cell line. IgG was purified from CHO cell culture supernatant by protein A chromatography.
Species Reactivity Human
Application Neutralization, ELISA
Application & Usage Neutralization : 1-20μg/ml; ELISA: 1μg/ml
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Panitumumab is the human monoclonal antibody against epidermal growth factor receptor (EGFR). The EGFR is a member of a subfamily of type I receptor tyrosine kinases, including EGFR (HERl, c-ErbB-l), HER2/neu, HER3, and HER4. EGFR is a transmembrane glycoprotein that is constitutively expressed in many normal epithelial tissues, including the skin and hair follicle. Overexpression of EGFR is also detected in many human cancers, including those of the colon and rectum. Panitumumab binds specifically and selectively to the EGFR, preventing binding of activating ligands, such as the EGF and transforming growth factor-α. This binding results in blockade of the essential downstream signaling pathways that are known to govern apoptosis, proliferation and differentiation of both normal and neoplastic cell types in a wide array of tissues.


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