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Anti-EGFR (Matuzumab), Human IgG1 Antibody

Monoclonal antibody to detect EGFR in human samples.
Catalog #: A1090
$625.00

Product Details

Cat # +Size A1090-200
Size 200 µg
Antibody Target EGFR
Alternate Name Epidermal Growth Factor Receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
Host Recombinant
Antibody Type Monoclonal
Isotype Human IgG1, kappa
Immunogen Domain III of the extracellular domain of human EGRF.
Accession # P00533
Gene ID 1956
Appearance Colorless liquid
Formulation 200 µg affinity purified human antibody in phosphate-buffered saline (PBS) containing 0.02% Proclin 300
Purification Affinity purified using protein A
Species Reactivity Human
Application Block; FC; WB
Handling The antibody solution should be gently mixed before use
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.


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