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Anti-Dopamine beta-Hydroxylase Antibody

Affinity purified rabbit polyclonal antibody to detect Dopamine beta-Hydroxylase expression in human and mouse samples
Catalog #: A2002
$320.00

Product Details

Size 100 µl
Antibody Target Dopamine beta-Hydroxylase
Alternate Name Dopamine beta-hydroxylase; Dopamine beta-monooxygenase
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Immunogen KLH-conjugated synthetic peptide targeting a sequence within the center region of human Dopamine beta-Hydroxylase
Accession # P09172
Gene ID 1621
Appearance Colorless liquid
Formulation In 0.42% Potassium phosphate; 0.87% NaCl; pH 7.3; 30% glycerol; and 0.01% sodium azide
Purification Affinity purified
Species Reactivity Mouse, Human
Application Western Blotting
Application & Usage WB 1:500 - 1:1000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neurosecretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders.


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