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Anti-Diglycyl-Lysine Antibody (Clone# GX41)

Mouse monoclonal antibody to detect peptides with diglycyl modified lysine in human, rat, mouse, chicken, cow, horse, and yeast
Catalog #: A2226
$325.00

Product Details

Cat # +Size A2226-100
Size 100 μg
Antibody Target Diglycyl-Lysine
Alternate Name Diglycyl-Lysine, Gly-Gly Lycine
Host Mouse
Antibody Type Monoclonal
Isotype IgG
Immunogen Linear peptide corresponding to Diglycyl Lysine
Appearance Lyophilized powder
Formulation In 0.2 M HEPES pH 8.5
Purification Protein A affinity chromatography
Species Reactivity Tested in Rat. Reactivity expected in Human, Mouse, Chicken, Bovine, Equine, Yeast
Application Immunoprecipitation (IP), Western Blotting
Application & Usage Western Blot, IP
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Ubiquitination is one of the most important post-translational modifications that determine the functional activity and stability of the protein. It plays a significant role in multiple biological processes such as cell proliferation, differentiation, regulation of cell cycle, gene transcription, and apoptosis. Changes in the ubiquitination of proteins are linked to diseases such as cancer, inflammation, neurodegenerative, and cardiovascular diseases. Thus, it could be a potential target for drug development. Protein ubiquitination can be identified by mutational experiments and tandem mass spectrometry (MS/MS). However, a new approach relies on an antibody-based detection wherein the antibody recognizes diglycyl-lysine peptide generated as a result of the digestion of protein sample by trypsin. BioVision’s Anti-Diglycyl-Lysine Antibody (Clone# GX41) can help identify the diglycyl lysine sequences that are present on the ε-amine of lysine as an adduct with no reactivity to unmodified lysine.


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