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Anti-Dectin-2 Monoclonal Antibody (Clone: ABM2H28)

Monoclonal antibody for the detection of Dectin-2 in cell and tissues
Catalog #: A1533

In stock

$235.00

Product Details

Cat # +Size A1533-50
Size 50 µg
Antibody Target Dectin-2
Alternate Name CLEC6A, CLECSF10, DECTIN2
Host Mouse
Antibody Type Monoclonal
Isotype IgG2 Kappa
Immunogen A partial length recombinant Dectin-2 protein (amino acids 70-230) was used as the immunogen
Accession # Q6EIG7
Gene ID 93978
Appearance Colorless Liquid
Formulation 0.5mg/ml in Supplied in PBS containing 0.05% BSA and 0.05% Sodium azide.
Purification Protein G Chromatography
Species Reactivity Human, mouse
Application WB, FACS, IHC
Application & Usage WB: 2-4 mg/ml; FACS: 0.5mg/106 cells; IHC: 5mg/ml
Handling The antibody solution should be gently mixed before use
Storage Conditions 4°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Dectin-2 (C-type lectin domain family 6 member A) is a type II membrane receptor with an extracellular C-type lectin-like domain fold. Dectin-2 plays an important role in the host defense against C. albicans infection by inducing TH17 cell differentiation. It binds high-mannose carbohydrates in a Ca(2+)-dependent manner. In Dectin-2 glycosylation occurs at Asn131, Asn170. Dectin-2 has 2 isoforms produced by alternative splicing. Dectin-2 is strongly expressed in monocytes and weakly in B-cells and also expressed in spleen, tonsils, lymph node, lungs, leukocytes, dendritic cells and bone marrow.


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