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Anti-Cyclin H Antibody (1H9-D3-E11)

Monoclonal antibody to detect Cyclin H
Catalog #: A1320
$265.00

Product Details

Cat # +Size A1320-100
Size 100 µg
Antibody Target Cyclin-H
Alternate Name Cyclin-H, MO15-associated protein, p34, p37
Host Mouse
Antibody Type Monoclonal
Isotype Mouse IgG2b
Immunogen Recombinant human Cyclin H protein fragments expressed in E.coli
Accession # P51946
Gene ID 902
Appearance Colorless liquid
Formulation In buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Purification Affinity purified
Species Reactivity Human
Application WB, IP
Positive Control WB: Jurkat, K562 and A431 cell lysates; IP: HeLa cell lysates
Application & Usage WB; 1:1000, IP
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.


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