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Anti-CTGF (Pamrevlumab), Human IgG1 Antibody

The biosimilar is a human monoclonal antibody that targets CTGF, a pro-inflammatory protein that plays a key role in the progression of fibrosis and other proliferation disorders
Catalog #: A2207
$455.00

Product Details

Cat # +Size A2207-100
Size 100 μg
Antibody Target CTGF
Alternate Name FG-3019, FG3019, CCN2, NOV2, HCS24, IGFBP8, IGFBP-8, IBP-8, IGF-Binding Protein 8, CCN Family Member 2
Host Recombinant
Antibody Type Monoclonal
Isotype IgG1, kappa
Immunogen Human CTGF
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In PBS, pH 7.5
Purification Protein A purified
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a fully human IgG1 monoclonal antibody that is directed against connective tissue growth factor (CTGF). CTGF is a cysteine-rich glycoprotein that is found in several cell types such as fibroblasts, smooth muscle cells, and cartilaginous cells. It is known to be involved in multiple pathological and biological processes such as angiogenesis, tumor development, skin diseases, and osteogenesis. Studies have demonstrated that increased CTGF expression is found in fibrotic lesions, which suggest its role in causing fibrosis. Fibrosis is one of the hallmarks of muscular dystrophies, resulting in weakness and injury of the muscles. Increased expression of CTGF is also observed in muscular dystrophies. Binding of the antibody to CTGF decreases fibrosis in muscles and improves the function of the muscles. The original drug received Fast Track designation from the FDA to treat idiopathic pulmonary fibrosis (IPF) and pancreatic cancer. Currently, the drug is undergoing clinical trials to treat Duchenne muscular dystrophy


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