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Anti-CoV-2 & SARS-CoV S1 Antibody (Clone# CR3022)

Recombinant monoclonal antibody to detect the expression of SARS-CoV-2 and SARS-CoV Spike S1 protein. This antibody was manufactured using recombinant platform with variable regions from B-cell clone CR3022. The monoclonal antibody, originally generated by sequencing peripheral blood lymphocytes of SARS-CoV infected patient, can bind to SARS-CoV-2 RBD at a KD of 6.3 nM.
Catalog #: A2103
$495.00

Product Details

Cat # +Size A2103-200
Size 200 μg
Antibody Target CoV-2 & SARS-CoV Spike S1
Alternate Name Spike protein; COVID19; COVID 19; S protein; SARS-CoV S protein; S glycoprotein; E2; Peplomer protein; Spike protein S1; SARS Coronavirus; SARS-CoV-2; SARS CoV 2; 2019-nCoV
Host Recombinant
Antibody Type Monoclonal
Isotype Human IgG1, kappa
Immunogen This antibody binds the amino acids 300-500 in the S1 domain of the SARS-CoV as well as SARS-CoV-2 Spike protein. The binding epitope is only accessible in the "open" conformation of the spike protein
Accession # P59594
Appearance Colorless liquid
Formulation In PBS with 0.02% Proclin 300
Purification Protein A affinity purified
Application ELISA
Application & Usage ELISA
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Coronaviruses (CoV) are a large group of enveloped positive-sense RNA viruses. They belong to subfamily Coronavirinae, in the family of Coronaviridae, of the order of Nidovirales. The Coronavirus genome is about 30 kb in length and encodes four structural proteins, namely, spike (S), envelope (E), membrane (M) and nucleocapsid (N), multiple nonstructural proteins and other accessory proteins. The Spike (S) protein is a 180 kDa type I glycosylated transmembrane protein, that assembles as a trimer on the surface of the virus, hence the coronavirus appears crown-shaped (In Latin, corona means crown). The ectodomain of the Spike protein consists of two domains: S1 domain whose main function is receptor binding, and S2 domain whose main function is membrane fusion. S1 binds to the cell surface receptor of host for attachment during the viral entry, this induces conformational change in the S2, thus enabling the fusion of host and viral membranes and ultimately entry of the viral genome in the host cell.


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