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Anti-COMT Antibody

Affinity purified rabbit polyclonal antibody to detect COMT expression in human, mouse, rat and monkey samples
Catalog #: A2003
$340.00

Product Details

Size 100 µl
Antibody Target Catechol-O-Methyltransferase
Alternate Name Catechol O-methyltransferase
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Immunogen KLH-conjugated synthetic peptide targeting a sequence within the center region of human COMT
Accession # P21964
Gene ID 1312
Appearance Colorless liquid
Formulation In 0.42% Potassium phosphate; 0.87% NaCl; pH 7.3; 30% glycerol; and 0.01% sodium azide
Purification Affinity purified
Species Reactivity Mouse, Monkey, Rat, Human
Application Immunofluorescence (IF), Western Blotting
Application & Usage WB 1:500 - 1:1000, IF 1:100 - 1:500
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.


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