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Anti-CNOT7 Antibody

Polyclonal antibody to detect endogenous levels of CNOT7 in human, mouse and rat.
Catalog #: A1235
$295.00

Product Details

Cat # +Size A1235-100
Size 100 µl
Antibody Target CNOT7
Alternate Name CAF1, CCR4-NOT transcription complex subunit 7, BTG1-binding factor 1, CCR4-associated factor 1, CAF-1, Caf1a
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CNOT7
Accession # Q9UIV1
Gene ID 29883
Appearance Colorless liquid
Formulation In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide
Purification Affinity purified
Species Reactivity Human, Mouse, Rat
Application WB, IH
Positive Control WB: HeLa, HuvEc, DKD, mouse brain, rat brain lysates ; IHC: human ovarian cancer tissue
Application & Usage WB; 1:500 – 1:2000, IH; 1:50 – 1:200
Handling The antibody solution should be gently mixed before use
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.


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