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Anti-Clathrin Antibody (CLC/1421)

Monoclonal Antibody to detect Clathrin in human samples
Catalog #: A1577
$395.00

Product Details

Cat # +Size A1577-100
Size 100 µg
Antibody Target Clathrin
Alternate Name Clathrin light chain A; Clathrin light chain B; Clathrin light chain LCA; Clathrin light chain LCB; Clathrin light polypeptide A; Clathrin light polypeptide B; Clathrin, light polypeptide (Lca); Clathrin, light polypeptide (Lcb); CLTA; CLTB
Host Mouse
Antibody Type Monoclonal
Isotype Mouse / IgG2b, kappa
Immunogen Purified recombinant N-terminal fragment of human Clathrin Light Chain
Accession # P09496 and P09497
Gene ID 1211 and 1212
Appearance Colorless liquid
Formulation Supplied in 10 mM PBS with 0.05% BSA & 0.05% azide
Purification Protein A/G purified
Species Reactivity Human
Application FC, IF, IHC
Positive Control IHC: Human Pancreas
Application & Usage FC: 0.5-1 µg/1X106 cells, IF: 1-2 µg/ml, IHC: 0.5-1 µg/ml for 30 minutes at RT
Handling The antibody solution should be gently mixed before use
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

This antibody recognizes proteins of 31-44 kDa, which are identified as Clathrin Light Chains (both A & B). Clathrin is composed of three heavy chains and three light chains, which associate non-covalently to form a triskelion structure. Clathrin light chain regulates the self-assembly of triskelions onto intracellular membranes. Clathrin light chain subunits (LCA and LCB) contribute to regulation of coated vesicle formation to sort proteins during receptor-mediated endocytosis and organelle biogenesis. LCA and LCB are encoded by two discrete genes. They share only 60% homology, and have certain features in common. Both LCA and LCB undergo alternative mRNA splicing, which results in the generation of tissue-specific isoforms.


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