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Anti-Citrullinated Myelin Basic Protein Polyclonal Antibody

An autoimmune biomarker in multiple sclerosis
Catalog #: A2320
SKU-Size Size Price Qty
A2320-50 50 µl
$195.00
A2320-100 100 µl
$325.00
More Sizes Get Quote

Product Details

Antibody Target Citrullinated human myelin basic protein
Alternate Name Myelin Membrane Encephalitogenic Protein; Myelin A1 Protein; Proline-Rich Proteoglycan 2; Golli-MBP; MBP
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide derived from human myelin basic protein (isoform 5) citrullinated at R122 and R130
Accession # P02686
Gene ID 4155
Appearance Liquid
Formulation PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Purification Peptide affinity purification
Species Reactivity Human
Application ELISA, Western Blotting
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Myelin basic protein (MBP) comprises several isoforms of a single gene product, which together make up a major component of the myelin sheath of oligodendrocytes and Schwann cells in the central nervous system. MBP contains 19 arginine residues that can be citrullinated by protein arginine deiminases (PADs), which will decrease the positive charge of the protein. The decrease in positive charge disrupts MBP interactions with the lipid membranes of myelin sheath cells. Citrullinated MBP is associated with demyelination and multiple sclerosis.


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