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Anti-Chromogranin A / CHGA Antibody (CGA/413 + CHGA/777 + CHGA/798)

Monoclonal Antibody to detect Chromogranin A/CHGA in human samples
Catalog #: A1576
$395.00

Product Details

Cat # +Size A1576-100
Size 100 µg
Antibody Target Chromogranin A / CHGA
Alternate Name Beta-Granin; CGA; CHGA; Chromogranin A Parathyroid Secretory Protein 1; ER-37; Pancreastatin; Parastatin; Parathyroid Secretory Protein 1; Pituitary Secretory Protein I; SP-I; Vasostatin I or II
Host Mouse
Antibody Type Monoclonal
Isotype Mouse / IgG's
Accession # P10645
Gene ID 1113
Appearance Colorless liquid
Formulation Supplied in 10 mM PBS with 0.05% BSA & 0.05% azide
Purification Protein A/G purified
Species Reactivity Human, Monkey, Pig, Mouse and Rat
Application FC, IF, IHC
Positive Control IHC: (A) Pheochromocytoma, (B) Pancreas, (C) Parathyroid, (D) Adrenal Gland
Application & Usage FC: 0.5-1 µg/1X106 cells in 0.1 ml, IF: 0.5-1 µg/ml, IHC: 0.25-0.5 µg/ml for 30 minutes at RT
Handling The antibody solution should be gently mixed before use
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.


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