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Anti-CHI3L1 Antibody

Rabbit polyclonal antibody to detect CHI3L1 expression in human, mouse, and rat samples
Catalog #: A2254
$340.00

Product Details

Cat # +Size A2254-100
Size 100 μl
Antibody Target CHI3L1
Alternate Name GP39, ASRT7, GP-39, YK-40, YKL40, CGP-39, YKL-40, YYL-40, HC-gp39, HCGP-3P, hCGP-39
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Immunogen KLH-conjugated synthetic peptide targeting a sequence within the center region of human YKL-40
Accession # P36222
Gene ID 1116
Appearance Colorless liquid
Formulation In 0.42% Potassium phosphate; 0.87% NaCl; pH 7.3; 30% glycerol; and 0.01% sodium azide
Purification Affinity purified
Species Reactivity Human, Rat, Mouse
Application Western Blotting
Application & Usage WB 1:500 - 1:1000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Chitinase 3-like 1 (CHI3L1, YKL-40) is a 40 kDa secreted glycoprotein that belongs to the glycoside hydrolase family 18. The protein is secreted by a variety of cells such as neutrophils, chondrocytes, macrophages, smooth muscle cells, and tumor cells. It contains a chitin-binding domain but lacks chitinase activity. The gene is located on chromosome 1q31-1q32. Genetic variations of CHI3L1 are associated with multiple inflammatory and neoplastic diseases. CHI3L1 plays a key role in protection against pathogens, inflammation, oxidant-, and antigen-induced injury responses, tissue repair. Higher levels of serum CHI3L1 are associated with poor prognosis and reduced survival in multiple cancers such as colon, gastric, breast, lung cancers, glioblastoma, sarcoma, and osteosarcoma. Increased levels of CHI3L1 are also associated with inflammatory conditions such as Crohn’s disease, rheumatoid arthritis, asthma, and chronic obstructive pulmonary disease (COPD). Therefore, CHI3L1 could serve as an efficient therapeutic target for the treatment of human diseases


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