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Anti-CFTR Antibody (SPM176)

Monoclonal Antibody to detect CFTR in human samples
Catalog #: A1575
$395.00

Product Details

Cat # +Size A1575-100
Size 100 µg
Antibody Target CFTR
Alternate Name ABC35; ATP Binding Cassette Superfamily C Member 7 (ABCC7); cAMP-dependent chloride channel; CFTR; CFTR/MRP; Channel conductance-controlling ATPase; Cystic Fibrosis Transmembrane Conductance Regulator; MRP7; TNR CFTR, ABCC7
Host Mouse
Antibody Type Monoclonal
Isotype Mouse / IgG2a
Immunogen Recombinant human full-length CFTR
Accession # P13569
Gene ID 1080
Appearance Colorless liquid
Formulation Supplied in 10 mM PBS with 0.05% BSA & 0.05% azide
Purification Protein A/G purified
Species Reactivity Human and Mouse
Application WB, IF, IHC
Positive Control IHC: Human Pancreas
Application & Usage WB: 0.5-1 µg/ml, IF: 0.5-1 µg/ml, IHC: 0.5-1.0 µg/ml for 30 minutes at RT
Handling The antibody solution should be gently mixed before use
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

This mAb recognizes a protein of 165-170 kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3', 5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.


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