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Anti-CD99 / MIC2 Antibody (MIC2/877)

Monoclonal Antibody to detect CD8A in human samples
Catalog #: A1571
$395.00

Product Details

Cat # +Size A1571-100
Size 100 µg
Antibody Target CD99 / MIC2
Alternate Name 12E7; E2 antigen; MIC 2X; MIC 2Y; MIC2; Protein MIC2; Surface antigen MIC2; T-cell surface glycoprotein E2
Host Mouse
Antibody Type Monoclonal
Isotype Mouse / IgG1, kappa
Immunogen Recombinant full-length human MIC2 protein
Accession # P14209
Gene ID 4267
Appearance Colorless liquid
Formulation Supplied in 10 mM PBS with 0.05% BSA & 0.05% azide
Purification Protein A/G purification
Species Reactivity Human, does not react with Rat.
Application FC, IF, IHC
Positive Control IHC: human Ewing's Sarcoma, human Ovarian Carcinoma, human Testicular Carcinoma
Application & Usage FC: 0.5-1 µg/1X106 cells in 0.1ml, IF: 0.5-1 µg/ml, IHC: 1-2 µg/ml for 30 minutes at RT
Handling The antibody solution should be gently mixed before use
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Recognizes a sialoglycoprotein of 27-32 kDa, identified as CD99, or MIC2 gene product, or E2 antigen. MIC2 gene is located in the pseudo-autosomal region of the human X and Y chromosome. MIC2 gene encodes two distinct proteins, which are produced by alternative splicing of the CD99 gene transcript and are identified as bands of 30 and 32 kDa (p30/32).Although its function is not fully understood, CD99 is implicated in various cellular processes including homotypic aggregation of T cells, upregulation of T cell receptor and MHS molecules, apoptosis of immature thymocytes and leukocyte diapedesis. CD99 is expressed on the cell membrane of some lymphocytes, cortical thymocytes, and granulosa cells of the ovary. Most pancreatic islet cells, Sertoli cells of the testis, and some endothelial cells express this antigen. Mature granulocytes express very little or no CD99. MIC2 is strongly expressed on Ewing's sarcoma cells and primitive peripheral neuroectodermal tumors.


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