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Anti-CD86 Antibody (Clone C86/1146)

Monoclonal Antibody to detect CD86 in human samples
Catalog #: A1569

In stock

$395.00

Product Details

Cat # +Size A1569-100
Size 100 µg
Antibody Target CD86
Alternate Name Activation B7-2 antigen; B lymphocyte activation antigen B72; CD28 antigen ligand 2; CD28LG2; CLS1; CTLA-4 counter-receptor B7.2; Early T-cell co-stimulatory molecule 1; ETC-1; FUN-1; LAB72; Ly-58; MB7-2; TS/A-2, B70, BU63, CD86, CD28LG2
Host Mouse
Antibody Type Monoclonal
Isotype Mouse / IgG1, kappa
Immunogen Recombinant human full-length CD86 protein
Accession # P42081
Gene ID 942
Appearance Colorless liquid
Formulation In 10 mM PBS with 0.05% BSA & 0.05% azide
Purification Protein A/G purification
Species Reactivity Human, Mouse and Rat
Application FC, IF, WB, IHC
Positive Control IHC: human Melanoma, FC: human PBMC's , WB: Daudi Cell Lysate
Application & Usage FC: 0.5-1 µg/1X106 cells in 0.1 ml, IF: 0.5-1 µg/ml, WB: 0.5-1 µg/ml, IHC: 2-4 µg/ml for 30 minutes at RT
Handling The antibody solution should be gently mixed before use
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

This antibody recognizes a protein of 70 kDa, which is identified as CD86. CD86 is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. CD86 expression is rapidly upregulated by B cell specific stimuli with peak expression at 18 to 42 hours after stimulation. CD86, along with CD80/B71, is an important accessory molecule in T cell co-stimulation via its interaction with CD28 and CD152/CTLA4. Since CD86 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response. It is also found on malignant Hodgkin and Reed Sternberg (HRS) cells in Hodgkin's disease.


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