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Anti-CD79B (Polatuzumab Vedotin), Humanized Antibody

The biosimilar is an antibody-drug conjugate that targets CD79B. Upon detachment from the antibody inside the cell, the drug disrupts microtubule network, which leads to cell cycle arrest, and apoptosis of malignant cells
Catalog #: A2178

Product Details

Cat # +Size A2178-100
Size 100 μg
Antibody Target CD79B
Alternate Name B29, IGB, AGM6, fcu 2711, Ro 5541077-000, DCDS4501A, RG7596
Host Recombinant
Antibody Type Monoclonal
Isotype IgG1, kappa
Immunogen Human CD79B
Accession # DB12240
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


The research-grade biosimilar is an antibody-drug conjugate that targets CD79B. CD79B is a transmembrane protein that plays an essential role in B-cell receptor signaling and is highly expressed on the surface of tumorigenic cells. The conjugate consists of Anti-CD79B humanized monoclonal antibody that is linked to a microtubule disrupting agent monomethyl auristatin E (MMAE) via a protease-cleavable linker. Upon internalization in the cell, the MMAE is detached from the antibody due to proteolytic cleavage. The MMAE then disrupts the microtubule network, which causes cell cycle arrest and apoptosis of tumorigenic cells. The original antibody-drug conjugate has been approved by the FDA to treat patients with relapsed or refractory diffuse large B-cell lymphoma in combination with bendamustine and rituximab.

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