Product Details
| Cat # +Size | A1567-100 |
|---|---|
| Size | 100 µg |
| Antibody Target | CD74 |
| Alternate Name | DHLAG, Gamma chain of class II antigens, HLA class II histocompatibility antigen gamma chain, HLA-DR antigens-associated invariant chain, HLADR-gamma (HLADG), Ia antigen-associated invariant chain, la-gamma, Major histocompatibility complex class II invariant chain, CLIP, MHC HLA-DR gamma chain, p33, CD74 |
| Host | Mouse |
| Antibody Type | Monoclonal |
| Isotype | Mouse / IgG1, kappa |
| Immunogen | SU-DHL-4 lymphoma cells |
| Accession # | P04233 |
| Gene ID | 972 |
| Appearance | Colorless liquid |
| Formulation | In 10 mM PBS with 0.05% BSA & 0.05% azide |
| Purification | Protein A/G purification |
| Species Reactivity | Human, Baboon and Mouse. Does not react with rat |
| Application | FC, IF, IHC |
| Positive Control | IHC: human Tonsil |
| Application & Usage | FC: 0.5-1 µg/1X106 cells in 0.1 ml, IF: 1-2 µg/ml, IHC: 1-2 µg/ml for 30 minutes at RT |
| Handling | The antibody solution should be gently mixed before use |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
It recognizes a protein of ~35 kDa, identified as CD74. CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating a typical fibroxanthoma (-) from malignant fibrous histiocytoma (+).
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