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Anti-CD74 Antibody (B-Cell Marker) (Clone LN-2)

Monoclonal Antibody to detect CD74 in human samples
Catalog #: A1567

In stock

$395.00

Product Details

Cat # +Size A1567-100
Size 100 µg
Antibody Target CD74
Alternate Name DHLAG, Gamma chain of class II antigens, HLA class II histocompatibility antigen gamma chain, HLA-DR antigens-associated invariant chain, HLADR-gamma (HLADG), Ia antigen-associated invariant chain, la-gamma, Major histocompatibility complex class II invariant chain, CLIP, MHC HLA-DR gamma chain, p33, CD74
Host Mouse
Antibody Type Monoclonal
Isotype Mouse / IgG1, kappa
Immunogen SU-DHL-4 lymphoma cells
Accession # P04233
Gene ID 972
Appearance Colorless liquid
Formulation In 10 mM PBS with 0.05% BSA & 0.05% azide
Purification Protein A/G purification
Species Reactivity Human, Baboon and Mouse. Does not react with rat
Application FC, IF, IHC
Positive Control IHC: human Tonsil
Application & Usage FC: 0.5-1 µg/1X106 cells in 0.1 ml, IF: 1-2 µg/ml, IHC: 1-2 µg/ml for 30 minutes at RT
Handling The antibody solution should be gently mixed before use
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

It recognizes a protein of ~35 kDa, identified as CD74. CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating a typical fibroxanthoma (-) from malignant fibrous histiocytoma (+).


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