Product Details
| Cat # +Size | A1556-100 |
|---|---|
| Size | 100 µg |
| Antibody Target | CD61 |
| Alternate Name | BDPLT2; GP3A; GPIIIa; GT; HPA 1; HPA 4; Integrin beta-3; ITGB3; NAIT; Platelet fibrinogen receptor beta subunit; Platelet glycoprotein IIIa; PTP |
| Host | Mouse |
| Antibody Type | Monoclonal |
| Isotype | Mouse / IgG1, kappa |
| Immunogen | Phytohemagglutinin (PHA)-stimulated peripheral blood cells |
| Accession # | P05106 |
| Gene ID | 3690 |
| Appearance | Colorless liquid |
| Formulation | In 10 mM PBS with 0.05% BSA & 0.05% azide |
| Purification | Protein A/G purification |
| Species Reactivity | Human |
| Application | FC, IF, IHC |
| Positive Control | IHC: human Spleen |
| Application & Usage | FC: 0.5-1 µg/1X106 cells in 0.1 ml, IF: 0.5-1 µg/ml, IHC: 1-2 µg/ml for 30 minutes at RT |
| Handling | The antibody solution should be gently mixed before use |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Reacts with human integrin beta-3 (GPIIIa, vitronectin receptor beta chain). It associates with the V-chain (CD51) to form vitronectin receptor, or with the IIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61). The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.
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