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Anti-CD6 (Itolizumab), Humanized Antibody

The biosimilar is a humanized monoclonal antibody that targets CD6 and inhibits T-cell activation and thus reduces inflammation
Catalog #: A2164
$455.00

Product Details

Cat # +Size A2164-100
Size 100 μg
Antibody Target CD6
Alternate Name T1h, XQQ2RHV14N, TP120, T12
Host Recombinant
Antibody Type Monoclonal
Isotype IgG1, kappa
Immunogen Human CD6
Appearance Colorless liquid
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a humanized recombinant IgG1 monoclonal antibody that specifically targets the scavenger receptor cysteine-rich (SRCR) distal domain 1 of CD6. CD6 is a co-stimulatory molecule that is primarily expressed on the T-cell surface and plays an important role in the maturation, activation, and differentiation of T-cells, and pro-inflammatory cytokine production. Binding of Itolizumab to CD6 prevents T-cell activation, decreases the levels of IFN-γ, IL-6, and TNF-α and thus reduces inflammation. The original drug was approved by the DCGI in India to treat moderate-to-severe plaque psoriasis. In 2020, the drug received approval to treat moderate-to-severe COVID-19 complications.


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