Product Details
| Cat # +Size | A1555-100 |
|---|---|
| Size | 100 µg |
| Antibody Target | CD6 |
| Alternate Name | T12; TP120, T-cell differentiation antigen CD6, CD6 |
| Host | Mouse |
| Antibody Type | Monoclonal |
| Isotype | Mouse / IgG1 |
| Immunogen | Human rheumatoid synovial T cell line ST-1 |
| Accession # | P30203 |
| Gene ID | 923 |
| Appearance | Colorless liquid |
| Formulation | In 10 mM PBS with 0.05% BSA & 0.05% azide |
| Purification | Protein A/G purification |
| Species Reactivity | Human |
| Application | FC, IF, IHC |
| Positive Control | IHC: human Tonsil |
| Application & Usage | FC: 0.5-1 µg/1X106 cells in 0.1 ml, IF: 0.5-1 µg/ml, IHC: 0.5-1 µg/ml for 30 minutes at RT |
| Handling | The antibody solution should be gently mixed before use |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular “scavenger receptor cysteine-rich” (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease.
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