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Anti-CD6 Antibody (Clone 3F7B5)

Monoclonal Antibody to detect CD6 in human samples
Catalog #: A1555
$395.00

Product Details

Cat # +Size A1555-100
Size 100 µg
Antibody Target CD6
Alternate Name T12; TP120, T-cell differentiation antigen CD6, CD6
Host Mouse
Antibody Type Monoclonal
Isotype Mouse / IgG1
Immunogen Human rheumatoid synovial T cell line ST-1
Accession # P30203
Gene ID 923
Appearance Colorless liquid
Formulation In 10 mM PBS with 0.05% BSA & 0.05% azide
Purification Protein A/G purification
Species Reactivity Human
Application FC, IF, IHC
Positive Control IHC: human Tonsil
Application & Usage FC: 0.5-1 µg/1X106 cells in 0.1 ml, IF: 0.5-1 µg/ml, IHC: 0.5-1 µg/ml for 30 minutes at RT
Handling The antibody solution should be gently mixed before use
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular “scavenger receptor cysteine-rich” (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease.


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