Product Details
| Cat # +Size | A1554-100 |
|---|---|
| Size | 100 µg |
| Antibody Target | CD59 |
| Alternate Name | 20kDa homologous restriction factor (HRF20); Complement regulatory protein; Human leukocyte antigen MIC11; MAC-inhibitory protein (MACIP); Membrane attack complex inhibition factor (MACIF); Membrane inhibitor of reactive lysis; MIRL; MSK21; Protectin; T cell activating protein, 1F5 antigen, HRF-20, HRF20, MAC-IP, MEM43 antigen, CD59 |
| Host | Mouse |
| Antibody Type | Monoclonal |
| Isotype | Mouse / IgG1, kappa |
| Immunogen | Recombinant full-length human CD59 protein |
| Accession # | P13987 |
| Gene ID | 966 |
| Appearance | Colorless liquid |
| Formulation | In 10 mM PBS with 0.05% BSA & 0.05% azide |
| Purification | Protein A/G purification |
| Species Reactivity | Human |
| Application | FC, IF, IHC |
| Positive Control | IHC: human Tongue, human Tonsil |
| Application & Usage | FC: 0.5-1 µg/1X106 cells in 0.1 ml, IF: 0.5-1 µg/ml, IHC: 1-2 µg/ml for 30 minutes at RT |
| Handling | The antibody solution should be gently mixed before use |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Reacts with human CD59, a 20 kDa glycosyl phosphatidyl-inositol (GPI)-anchored cell surface protein. CD59 regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. It inhibits formation of MAC, thus protecting cells from complement-mediated lysis. Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH). This mAb is useful for study on GPI-anchored proteins, PNH and CD59 functions. CD59 is widely distributed on cells in all tissues. The expression of CD59 on erythrocytes is important for their survival.
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