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Anti-CD5 Rabbit Monoclonal Antibody (RM314)

Rabbit monoclonal antibody to detect CD5 in human samples.
Catalog #: A1833
$250.00

Product Details

Cat # +Size A1833-50
Size 50 µl
Antibody Target CD5
Host Rabbit
Antibody Type Monoclonal
Isotype Rabbit IgG
Immunogen A peptide corresponding to the C-terminus of human CD5
Accession # P15144
Gene ID 290
Appearance Liquid
Formulation 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Purification Protein A affinity purified from an animal origin–free culture supernatant
Species Reactivity Human
Application Immunohistochemistry (IHC), Western Blotting
Application & Usage Western Blot: 1:1000-1:2000, IHC:1:500-1:1000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The CD5 antigen is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. Anti-CD5 is a pan T-cell marker that also reacts with a range of neoplastic B-cells, e.g. chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma, and a subset (~10%) of diffuse large B-cell lymphoma. CD5 aberrant expression is useful in making a diagnosis of mature T-cell neoplasms. Anti-CD5 detection is diagnostic in CLL/SLL within a panel of other B-cell markers, especially one that includes anti-CD23. Anti-CD5 is also very useful in differentiating among mature small lymphoid cell malignancies. In addition, anti-CD5 can be used in distinguishing thymic carcinoma (+) from thymoma (-). Anti-CD5 does not react with granulocytes or monocytes.


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