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Anti-CD45 / LCA Antibody (Clone 135-4C5)

Monoclonal Antibody to detect CD45 / LCA in human samples
Catalog #: A1540
$395.00

Product Details

Cat # +Size A1540-100
Size 100 µg
Antibody Target CD45 / LCA
Alternate Name B220, CD45R, GP180, Leukocyte common antigen (LCA), Loc, Ly-5, Lyt-4, Protein tyrosine phosphatase receptor type C (PTPRC), Receptor-type tyrosine-protein phosphatase C, T200 glycoprotein
Host Mouse
Antibody Type Monoclonal
Isotype Mouse / IgG2b, kappa
Immunogen Stimulated human leukocytes
Accession # P08575
Gene ID 5788
Appearance Colorless liquid
Formulation In 10 mM PBS with 0.05% BSA & 0.05% azide
Purification Protein A/G purification
Species Reactivity Human
Application FC, IF, IHC
Positive Control IHC: human Tonsil
Application & Usage FC: 0.5-1 µg/1X106 cells in 0.1 ml, IF: 0.5-1 µg/ml, IHC: 0.5-1 µg/ml for 30 minutes at RT
Handling The antibody solution should be gently mixed before use
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphotyrosine phosphatase. This mAb reacts with all isoforms of CD45R expressed by all hematopoietic cells, except erythrocytes, having a higher level of expression on lymphocytes than on granulocytes. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.


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