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Anti-CD44v6 Antibody (Clone CD44v6/1246)

Monoclonal Antibody to detect CD44v6 in human samples
Catalog #: A1527
$395.00

Product Details

Cat # +Size A1527-100
Size 100 µg
Antibody Target CD44v6
Alternate Name LHR; BA-1; chondroitin sulfate proteoglycan 8 (CSPG8); Epican; Extracellular Matrix Receptor III (ECM III); GP90 Lymphocyte Homing Adhesion Receptor; HCAM; HCELL; hematopoietic cell E- and L-selectin ligand; Heparan Sulfate Proteoglycan; Hermes Antigen; H
Host Mouse
Antibody Type Monoclonal
Isotype Mouse / IgG2a, kappa
Immunogen Recombinant fragment corresponding to the v6 domain of human CD44 (exact sequence is proprietary)
Accession # P16070
Gene ID 960
Appearance Colorless liquid
Formulation In 10 mM PBS with 0.05% BSA & 0.05% azide
Purification Protein A/G purification
Species Reactivity Human
Application FC, IF, IHC
Positive Control IHC: human Cervical Carcinoma, human Tongue Carcinoma
Application & Usage FC: 0.5-1 µg/1X106 cells , IF: 0.5-1 µg/ml, IHC: 0.5-1 µg/ml for 30 minutes at RT
Handling The antibody solution should be gently mixed before use
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

This antibody recognizes an epitope encoded by exon v6 on the variant portion of human CD44. The CD44 molecule belongs to a family of cellular adhesion molecules found on a wide range of normal and malignant cells in epithelial, mesothelial and hemopoiesis tissues. CD44 is a single gene with 20 exons, of which 10 are normally expressed to encode the basic CD44 (H-CAM) molecule. The additional 10 exons (v1 to v10) are only expressed by alternative splicing of the nuclear RNA. The expression of specific cell adhesion molecule CD44 splice variants has been reported to be associated with metastasis in certain human malignancies.


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