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Anti-CD40L (Ruplizumab), Human IgG1 Antibody

Monoclonal antibody to detect CD40L in human samples.
Catalog #: A1094
$625.00

Product Details

Cat # +Size A1094-200
Size 200 µg
Antibody Target CD40LG
Alternate Name CD40 ligand; tumour necrosis factor ligand superfamily member 5; TNFSF5; CD154; tumour necrosis factor related activation protein; TRAP
Host Recombinant
Antibody Type Monoclonal
Isotype Human IgG1, kappa
Immunogen Human CD40L
Accession # P29965
Gene ID 959
Appearance Colorless liquid
Formulation 200 µg affinity purified human antibody in phosphate-buffered saline (PBS) containing 0.02% Proclin 300
Purification Affinity purified using protein A
Species Reactivity Human
Application Block; FC
Handling The antibody solution should be gently mixed before use
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cytokine that binds to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching. The antibody binds specifically to CD40L, a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. The antibody neutralizes CD40L function, as it blocks the interaction between CD40 and CD40L. When injected into cynomolgus monkeys, the antibody was found to have a T1/2 of 531  ± 155 hours.


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