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Anti-CD4 (Clenoliximab), Human IgG4 Antibody

Monoclonal antibody to detect CD4 in human and chimpanzee samples.
Catalog #: A1091
$625.00

Product Details

Cat # +Size A1091-200
Size 200 µg
Antibody Target CD4
Alternate Name p55; T cell surface antign T4/Leu-3.
Host Recombinant
Antibody Type Monoclonal
Isotype Human IgG4, lambda
Immunogen Domain 1 of human CD4.
Accession # P01730
Gene ID 920
Appearance Colorless liquid
Formulation 200 µg affinity purified human antibody in phosphate-buffered saline (PBS) containing 0.02% Proclin 300
Purification Affinity purified using protein A
Species Reactivity Human, Chimpanzee
Application ELISA; FC; Block; SPR; IHC
Handling The antibody solution should be gently mixed before use
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The antibody binds specifically to CD4, a molecule which is part of the immunolgobulin super-family, expressed on the surface of helper T cells. The CD4 molecule acts as a co-receptor in the activation of T cells, aiding the interaction between the TCR and MHC II of the antigen-presenting cell. The antibody is classified as "primatized", as the variable regions of the light and heavy chains are obtained from primates, while the lamda light chain and γ4 heavy chain constant domains are human. The antibody was engineered from the primatized IgG1 monoclonal antibody Keliximab by substituting two key residues. The role of the antibody as an immunosuppressor has been tested in vivo, by intravenous administration in chimpanzees and human volunteers. The antibody reached Phase II clinical trials with Biogen-Idec.


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