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Anti-CD38 (Isatuximab) Humanized Antibody

A tumor biomarker that is overexpressed in multiple myeloma
Catalog #: A2319
SKU-Size Size Price Qty
A2319-50 50 μg
$225.00
A2319-100 100 μg
$395.00
More Sizes Get Quote

Product Details

Antibody Target Human CD38
Alternate Name ADPRC1; cADPr hydrolase 1; T10; Cluster of differentiation 38; CD38 Antigen (P45)
Host CHO cells
Antibody Type Monoclonal
Isotype IgG1-kappa
Immunogen Human CD38
Accession # P28907
Gene ID 952
Appearance Liquid
Formulation PBS pH 7.5
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC (6 months), -80ºC (Long term)
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a human IgG1 kappa monoclonal antibody that targets CD38, a type II transmembrane glycoprotein that is expressed on lymphoid cells, myeloid cells, and non-hematopoietic cells and performs several cell signaling functions. It is overexpressed on multiple myeloma cells. The antibody binds to CD38 and induces tumor cell death via diverse mechanisms such as antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC) and antibody-dependent cellular phagocytosis. Antibody-dependent cellular cytotoxicity is mediated by the binding of the Fc region of the antibody with FcR of NK cells; complement-dependent cytotoxicity is mediated by the binding of the Fc region of the antibody with C1q, followed by the initiation of the complement cascade; antibody-dependent cellular phagocytosis is mediated by binding of the Fc region of the antibody with the FcR of the macrophage. The original biosimilar was approved for the treatment of multiple myeloma in 2020.


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