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Anti-CD38 (Daratumumab), Human IgG1 Antibody

The biosimilar is a human monoclonal antibody that targets CD38 overexpressed on multiple myeloma cells and induces apoptosis via antibody and complement-dependent cell cytotoxicity. The original drug was FDA approved for the treatment of multiple myeloma
Catalog #: A2151
$455.00

Product Details

Cat # +Size A2151-100
Size 100 μg
Antibody Target CD38
Alternate Name HuMax-CD 38, HuMax-CD38, JNJ-54767414, ADPRC1, ADPRC 1
Host Recombinant
Antibody Type Monoclonal
Isotype IgG1, kappa
Immunogen Human CD38
Accession # DB09331
Appearance Colorless liquid
Concentration 1 mg/ml
Purification Protein A purified
Species Reactivity Human
Application In vitro studies
Application & Usage In vitro studies
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a human IgG1 kappa monoclonal antibody that targets CD38, a type II transmembrane glycoprotein that is expressed on lymphoid cells, myeloid cells, and non-hematopoietic cells and performs several cell signaling functions. It is overexpressed on multiple myeloma cells. The antibody binds to CD38 and induces tumor cell death via diverse mechanisms such as antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC) and antibody-dependent cellular phagocytosis. Antibody-dependent cellular cytotoxicity is mediated by the binding of the Fc region of the antibody with FcR of NK cells; complement-dependent cytotoxicity is mediated by the binding of the Fc region of the antibody with C1q, followed by the initiation of the complement cascade; antibody-dependent cellular phagocytosis is mediated by binding of the Fc region of the antibody with the FcR of the macrophage. The original drug received FDA approval in 2015 to treat multiple myeloma


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