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Anti-CD34 Rabbit Monoclonal Antibody

Monoclonal antibody to detect CD34 in human samples.
Catalog #: A1603

In stock

$295.00

Product Details

Cat # +Size A1603-50
Size 50 µl
Antibody Target CD34
Alternate Name CD34; Hematopoietic progenitor cell antigen CD34, Hematopoietic Progenitor Cell Antigen, HPCA1, Mucosialin
Host Rabbit
Antibody Type Monoclonal
Isotype Rabbit IgG
Immunogen A peptide corresponding to the C-terminus of human CD34
Accession # P28906
Gene ID 947
Appearance Colorless liquid
Formulation In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Purification Affinity purified
Species Reactivity Human
Application WB, IHC
Positive Control WB: mouse spleen tissue lysate, IHC: human kidney tissue section
Application & Usage WB: 1:100-1:200, IHC: 1:100-1:200
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

This mAb recognizes a single chain, transmembrane, heavily glycosylated protein of 90-120kDa, which is identified as CD34. On the basis of differential sensitivity to degradation by specific enzymes, epitopes of monoclonal antibodies to CD34 are classified into a three main categories, class I, class II and class III. It is a class II antibody whose epitope is resistant to neuraminidase but sensitive to glycoprotease and chymopapain. CD34 expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, CD34 is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. Its expression is also found in vascular endothelium. Additionally, it appears that proliferating endothelial cells express this molecule more than the non-proliferating endothelial cells. Anti-CD34 labels > 85% of angiosarcoma and Kaposi’s sarcoma, but with a lower specificity.


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