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Anti-CD34 Antibody (QBEnd/10)

Monoclonal Antibody to detect CD34 in human, Cynomolgus Monkey, Rhesus Monkey samples
Catalog #: A1497
$395.00

Product Details

Cat # +Size A1497-100
Size 100 µg
Antibody Target CD34
Alternate Name Hematopoietic Progenitor Cell Antigen, HPCA1, Mucosialin
Host Mouse
Antibody Type Monoclonal
Isotype Mouse / IgG1, kappa
Immunogen Detergent solubilized vesicular suspension prepared from human term placenta
Accession # P28906
Gene ID 947
Appearance Colorless liquid
Formulation In 10 mM PBS with 0.05% BSA & 0.05% azide
Purification Protein A/G purification
Species Reactivity Human, Cynomolgus Monkey, Rhesus Monkey
Application FC, IF, IHC
Positive Control IHC: human Tonsil
Application & Usage FC: 0.5-1ug/1X106 cells in 0.1ml, IF: 0.5-1ug/ml, IHC: 0.25-0.5ug/ml for 30 minutes at RT
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

This mAb recognizes a single chain, transmembrane, heavily glycosylated protein of 90-120kDa, which is identified as CD34. On the basis of differential sensitivity to degradation by specific enzymes, epitopes of monoclonal antibodies to CD34 are classified into a three main categories, class I, class II and class III. It is a class II antibody whose epitope is resistant to neuraminidase but sensitive to glycoprotease and chymopapain. CD34 expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, CD34 is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. Its expression is also found in vascular endothelium. Additionally, it appears that proliferating endothelial cells express this molecule more than the non-proliferating endothelial cells. Anti-CD34 labels > 85% of angiosarcoma and Kaposi’s sarcoma, but with a lower specificity.


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