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Product Details
| Cat # +Size | A2177-100 |
|---|---|
| Size | 100 μg |
| Antibody Target | CD30 |
| Alternate Name | cAC10-vcMMAE, SGN 35, SGN-35, Ki-1, D1S166E, TNFRSF8 |
| Host | Human/Mouse chimeric |
| Antibody Type | Monoclonal |
| Isotype | IgG1, kappa |
| Immunogen | Human CD30 |
| Accession # | DB08870 |
| Gene ID | 943 |
| Appearance | Colorless liquid |
| Concentration | Lot specific |
| Formulation | In PBS, pH 7.5 |
| Purification | Protein A purified |
| Species Reactivity | Human |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -80°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
The research-grade biosimilar is a recombinant antibody to Brentuximab without the drug conjugation. The original antibody-drug conjugate (Brentuximab Vedotin) consists of an Anti-CD30 human-mouse chimeric IgG1 antibody that is linked to a microtubule disrupting agent monomethyl auristatin E (MMAE) via a protease-cleavable linker. Upon internalization in the cell, the MMAE is detached from the antibody due to proteolytic cleavage. The MMAE then disrupts the microtubule network, which causes cell cycle arrest and results in apoptosis of tumorigenic cells. The original ADC received approval from the FDA to treat adult patients with relapsed or refractory Hodgkin’s lymphoma and systemic anaplastic large cell lymphoma.
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