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Anti-CD30 (Brentuximab), Chimeric Antibody

The biosimilar is a recombinant antibody to Brentuximab without the drug conjugation. The original antibody-drug conjugate (Brentuximab Vedotin) targets CD-30 and induces apoptosis of tumor cells via cell cycle arrest
Catalog #: A2177
$455.00

Product Details

Cat # +Size A2177-100
Size 100 μg
Antibody Target CD30
Alternate Name cAC10-vcMMAE, SGN 35, SGN-35, Ki-1, D1S166E, TNFRSF8
Host Human/Mouse chimeric
Antibody Type Monoclonal
Isotype IgG1, kappa
Immunogen Human CD30
Accession # DB08870
Gene ID 943
Appearance Colorless liquid
Concentration Lot specific
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a recombinant antibody to Brentuximab without the drug conjugation. The original antibody-drug conjugate (Brentuximab Vedotin) consists of an Anti-CD30 human-mouse chimeric IgG1 antibody that is linked to a microtubule disrupting agent monomethyl auristatin E (MMAE) via a protease-cleavable linker. Upon internalization in the cell, the MMAE is detached from the antibody due to proteolytic cleavage. The MMAE then disrupts the microtubule network, which causes cell cycle arrest and results in apoptosis of tumorigenic cells. The original ADC received approval from the FDA to treat adult patients with relapsed or refractory Hodgkin’s lymphoma and systemic anaplastic large cell lymphoma.


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