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Anti-CD30 (Brentuximab Vedotin), Chimeric Antibody

The biosimilar is an antibody-drug conjugate that targets CD-30, which is highly expressed on tumor cells. Upon detachment from the antibody inside the cell, the drug disrupts the microtubule network, which leads to cell cycle arrest, and apoptosis of malignant cells
Catalog #: A2177
$455.00

Product Details

Cat # +Size A2177-100
Size 100 μg
Antibody Target CD30
Alternate Name cAC10-vcMMAE, SGN 35, SGN-35, Ki-1, D1S166E, TNFRSF8
Host Human/Mouse chimeric
Antibody Type Monoclonal
Isotype IgG1, kappa
Immunogen Human CD30
Accession # DB08870
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is an antibody-drug conjugate that targets CD30. The conjugate consists of an Anti-CD30 human-mouse chimeric IgG1 antibody that is linked to a microtubule disrupting agent monomethyl auristatin E (MMAE) via a protease-cleavable linker. Upon internalization in the cell, the MMAE is detached from the antibody due to proteolytic cleavage. The MMAE then disrupts the microtubule network, which causes cell cycle arrest and results in apoptosis of tumorigenic cells. The original drug received approval from the FDA to treat adult patients with relapsed or refractory Hodgkin’s lymphoma and systemic anaplastic large cell lymphoma.


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