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Anti-CD27 Antibody (LPFS2/1611)

Monoclonal Antibody to detect CD27 in human samples
Catalog #: A1483
$395.00

Product Details

Cat # +Size A1483-100
Size 100 µg
Antibody Target CD27
Alternate Name LPFS2; S152; T cell activation antigen S152; T-cell activation antigen CD27; T14; TNFRSF7; TNFSF7; Tp55; Tumor necrosis factor receptor superfamily member 7
Host Mouse
Antibody Type Monoclonal
Isotype Mouse / IgG1
Immunogen Recombinant human CD27 protein (exact sequence is proprietary)
Accession # P26842
Gene ID 939
Appearance Colorless liquid
Formulation In 10 mM PBS with 0.05% BSA & 0.05% azide
Purification Protein A/G purification
Species Reactivity Human
Application FC, IF, IHC
Positive Control IHC: human Tonsil
Application & Usage FC: 0.5-1 ug/1X106 cells, IF: 0.5-1 ug/ml, IHC: 0.5-1 ug/ml for 30 minutes at RT
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Recognizes a protein of a disulfide-linked 120kDa dimer, identified as CD27. It is expressed on the majority of peripheral T cells, medullary thymocytes, memory-type B cells, and natural killer cells. It is a transmembrane phosphoglycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD27 binds to its ligand CD70, a member of the TNF family, and induces T-cell co-stimulation and B-cell activation. It also interacts with TRAFs and is involved in activation of NF-κB and SAPK/JNK and induces apoptosis.


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