Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]


Anti-CD22 (Inotuzumab Ozogamicin), Humanized Antibody

The biosimilar is an antibody-drug conjugate that targets CD22 that is highly expressed on the B cell surface. Upon detachment from the antibody inside the cell, the drug causes double-stranded DNA breaks, which leads to cell cycle arrest, and apoptosis of tumor cells
Catalog #: A2179

Product Details

Cat # +Size A2179-100
Size 100 μg
Antibody Target CD22
Alternate Name CMC 544, CMC-544, CMC544, PF-05208773, WAY-207294, Way 207294, SIGLEC2, SIGLEC-2
Host Recombinant
Antibody Type Monoclonal
Isotype IgG4, kappa
Immunogen Human CD22
Accession # DB05889
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


The research-grade biosimilar is an antibody-drug conjugate that is directed to CD22 which is highly expressed on the surface of B cells. The conjugate consists of Anti-CD22 humanized monoclonal antibody that is linked to a cytotoxic drug N-acetyl-gamma-calicheamicin via 4-(4 acetylphenoxy) butanoic acid (acetyl butyrate) linker. Upon internalization in the cell, the drug is detached from the antibody by hydrolytic cleavage. The drug binds to the minor groove of the DNA and forms a diradical species. This diradical species abstracts hydrogen ions from the phosphodiester bonds of DNA and causes double-strand DNA breaks, which leads to cell cycle arrest and apoptosis of the tumorigenic cells. The original antibody-drug conjugate is approved by the FDA to treat acute myeloid leukemia. It is also approved to treat adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL).

Why buy BioVision Products?
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.