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Anti-CD22 (Inotuzumab Ozogamicin), Humanized Antibody

The biosimilar is an antibody-drug conjugate that targets CD22 that is highly expressed on the B cell surface. Upon detachment from the antibody inside the cell, the drug causes double-stranded DNA breaks, which leads to cell cycle arrest, and apoptosis of tumor cells
Catalog #: A2179
$455.00

Product Details

Cat # +Size A2179-100
Size 100 μg
Antibody Target CD22
Alternate Name CMC 544, CMC-544, CMC544, PF-05208773, WAY-207294, Way 207294, SIGLEC2, SIGLEC-2
Host Recombinant
Antibody Type Monoclonal
Isotype IgG4, kappa
Immunogen Human CD22
Accession # DB05889
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is an antibody-drug conjugate that is directed to CD22 which is highly expressed on the surface of B cells. The conjugate consists of Anti-CD22 humanized monoclonal antibody that is linked to a cytotoxic drug N-acetyl-gamma-calicheamicin via 4-(4 acetylphenoxy) butanoic acid (acetyl butyrate) linker. Upon internalization in the cell, the drug is detached from the antibody by hydrolytic cleavage. The drug binds to the minor groove of the DNA and forms a diradical species. This diradical species abstracts hydrogen ions from the phosphodiester bonds of DNA and causes double-strand DNA breaks, which leads to cell cycle arrest and apoptosis of the tumorigenic cells. The original antibody-drug conjugate is approved by the FDA to treat acute myeloid leukemia. It is also approved to treat adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL).


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