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Anti-CD209 recMAb™ Antibody

Recombinant rabbit monoclonal antibody to detect the expression of CD209 in human samples
Catalog #: A2193
$370.00

Product Details

Cat # +Size A2193-100
Size 100 μg
Antibody Target CD209
Alternate Name CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, CIRE, DCSIGN, SIGNR5, SIGN-R1
Host Rabbit
Antibody Type Monoclonal
Isotype IgG
Immunogen Recombinant full-length human CD209 protein
Accession # Q9NNX6
Gene ID 30835
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In 10 mM PBS
Purification Protein A/G purified
Species Reactivity Human
Application Immunohistochemistry (IHC)
Application & Usage IHC (1-2 µg/ml)
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including leprosy and tuberculosis mycobacteria, the Ebola, hepatitis C, HIV-1 and Dengue viruses, and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain, a transmembrane region, and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CLEC4M (Gene ID: 10332), also known as L-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression on the surface of dendritic cells. Polymorphisms in the neck region are associated with protection from HIV-1 infection, while single nucleotide polymorphisms in the promoter of this gene are associated with differing resistance and susceptibility to and severity of the infectious disease, including rs4804803, which is associated with SARS severity.


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