Product Details
| Cat # +Size | A1594-50 |
|---|---|
| Size | 50 µl |
| Antibody Target | CD20 |
| Alternate Name | B-lymphocyte antigen CD20, B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member |
| Host | Rabbit |
| Antibody Type | Monoclonal |
| Isotype | Rabbit IgG |
| Immunogen | A peptide corresponding to the C-terminus of human CD20 |
| Accession # | P11836 |
| Gene ID | 931 |
| Appearance | Colorless liquid |
| Formulation | In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide |
| Purification | Affinity purified |
| Species Reactivity | Human |
| Application | WB, IHC |
| Positive Control | WB: Raji cell lysate; IHC: human tonsil tissue |
| Application & Usage | WB: 1:1000-1:2000, IHC: 1:500-1:1000 |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
It is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. This mAb can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood and B cell localization in tissues. It reacts with the majority of B-cells present in peripheral blood and lymphoid tissues and their derived lymphomas. In lymphoid tissue, germinal center blasts and B-immunoblasts are particularly reactive. It is a reliable antibody for ascribing a B-cell phenotype in known lymphoid tissues. Rarely, CD20-positive T-cell lymphomas have been reported. Reactivity has also been noted with Reed-Sternberg cells in cases of Hodgkin s disease, particularly of lymphocyte predominant type.
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