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Anti-CD20 (Obinutuzumab), Humanized Antibody

The biosimilar is a type II humanized monoclonal antibody that targets CD20 and induces B-cell lysis via antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis
Catalog #: A2180
$455.00

Product Details

Cat # +Size A2180-100
Size 100 μg
Antibody Target CD20
Alternate Name GA-101, GA101, R7159, RG7159, RO5072759, B1, S7, Bp35, CVID5, MS4A2, MS4A1, LEU-16
Host Recombinant
Antibody Type Monoclonal
Isotype IgG1, kappa
Immunogen Human CD20
Accession # DB08935
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Application & Usage In vitro studies
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is Type II humanized monoclonal antibody that targets CD20 expressed on pre- and mature B lymphocyte cells. The antibody is glycoengineered to increase the binding of CD 64 and CD16 by 7-10 folds and improve antibody-dependent cellular cytotoxicity (ADCC). Additionally, the glycoengineered structure of the antibody helps recruit immune effector cells such as polymorphonuclear neutrophils (PMNs), which when activated, release inflammatory mediators, and promote phagocytosis. A previous study demonstrated that the binding of the antibody to CD20 causes rearrangement of the actin cytoskeleton, which causes the lysosomal compartment to expand. As a result, the lysosomal membrane becomes permeable, causing Cathepsin B to leak into the cytosol. Excessive leakage of Cathepsin B promotes cell death by necrosis. The original drug has been approved by the FDA to treat patients with chronic lymphocytic leukemia (CLL) in combination with Chlorambucil.


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