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Anti-CD19/CD3ε (Blinatumomab), Bispecific Antibody

The biosimilar is a bispecific monoclonal antibody that targets both CD19 on malignant B cells and CD3ε on T-cells and causes caspase-mediated cell death. The original monoclonal antibody is approved to treat acute lymphoblastic leukemia
Catalog #: A2225
$465.00

Product Details

Cat # +Size A2225-100
Size 100 μg
Antibody Target CD19/CD3ε
Alternate Name AMG103, BITE MT-103, MEDI-538, MT103, bscCD19xCD3, MEDI 538, MEDI538, MT 103, B4, CVID3, CD19, T3E, TCRE, IMD18, CD3E
Host Recombinant
Antibody Type Monoclonal
Isotype (scFv-kappa-heavy)-(scFv-heavy-kappa)
Immunogen Human CD19/CD3ε
Accession # DB09052
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is a bispecific T-cell engager monoclonal antibody that targets both CD19 and CD3ε. A single molecule of this antibody possesses two binding sites: one for CD3ε expressed on T-cells and second for CD19 expressed on B-cells. The antibody forms a synapse between T-cells and malignant B-cells. Upon interaction, T-cells are activated, which release cytotoxic granules such as perforins and granzymes. Granzymes enter the cell cytoplasm with the help of perforins and initiate cell death pathways via activation of caspases. The original antibody has been approved by the FDA to treat relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL) in both adults and children


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