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Anti-CD162 Antibody (PSGL1/1601)

Monoclonal Antibody to detect CD162 in human samples
Catalog #: A1477

In stock

$395.00

Product Details

Cat # +Size A1477-100
Size 100 µg
Antibody Target CD162
Alternate Name CD162; CLA; Cutaneous lymphocyte associated antigen; P-selectin glycoprotein ligand 1; PSGL1; Selectin P ligand; SELPLG
Host Mouse
Antibody Type Monoclonal
Isotype Mouse / IgG1
Immunogen Recombinant human full-length SELPLG (CD162) protein
Accession # Q14242
Gene ID 6404
Appearance Colorless liquid
Formulation In 10 mM PBS with 0.05% BSA & 0.05% azide
Purification Protein A/G purification
Species Reactivity Human
Application FC, IF, IHC
Positive Control IHC: human Spleen, human Tonsil
Application & Usage FC: 0.5-1 ug/1X106 cells, IF: 0.5-1 ug/ml, IHC: 1-2 ug/ml
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CD162 glycoprotein functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response.


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