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Anti-CD10 Rabbit Monoclonal Antibody (RM337)

Affinity purified Rabbit monoclonal to CD10
Catalog #: A1850
$250.00

Product Details

Cat # +Size A1850-50
Size 50 µl
Antibody Target CD10
Host Rabbit
Antibody Type Monoclonal
Isotype Rabbit IgG
Immunogen A peptide corresponding to the N-terminus of human CD10.
Accession # P08473
Gene ID 4311
Appearance Liquid
Formulation 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Purification Protein A affinity purified from an animal origin–free culture supernatant
Species Reactivity Human
Application Immunohistochemistry (IHC), Western Blotting
Application & Usage IHC: 1:200-1:500, Western Blot: 1:1000-12000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cluster of differentiation 10 (CD10), membrane metallo-endopeptidase, neutral endopeptidase (NEP), Neprilysin, and common acute lymphoblastic leukemia antigen (CALLA), is a 90-110-kDa type II transmembrane glycoprotein normally expressed by a variety of tissues, including epithelial cells of the prostate, kidney, intestine, endometrium, adrenal glands, and lung. This zinc-dependent metalloprotease enzyme cleaves peptide bonds on the amino side of hydrophobic residues and inactivates a variety of physiologically active secreted peptides. CD20 is thought to be the rate-limiting degrading enzyme of amyloid β peptide (Aβ) whose abnormal misfolding and aggregation in neural tissue has been implicated in the development of Alzheimer's disease (AD). CD10 is also identified as the common acute lymphoblastic leukemia antigen (CALLA) present on leukemic cells of pre-B phenotype, and thus serves as the most important biomarker in the diagnosis of human acute lymphocytic leukemia (ALL).


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