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Anti-CCR5 (Leronlimab), Humanized Antibody

The biosimilar is an investigational humanized monoclonal antibody that targets CCR5, a cellular receptor that plays an important role in HIV infection, metastasis of the tumors and other diseases, including NASH
Catalog #: A2181
$455.00

Product Details

Cat # +Size A2181-100
Size 100 μg
Antibody Target CCR5
Alternate Name PA14, PRO 140, PRO-140, PRO140, HuPRO-140, CKR5, CCR-5, CD195, CKR-5, CCCKR5, CMKBR5, IDDM22, CC-CKR-5
Host Recombinant
Antibody Type Monoclonal
Isotype IgG4, kappa
Immunogen Human CCR5
Accession # DB05941
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation In PBS, pH 7.5
Purification Protein A purified
Species Reactivity Human
Handling The antibody solution should be gently mixed before use.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The research-grade biosimilar is an investigational humanized IgG4 monoclonal antibody that specifically inhibits CCR5. CCR5 is a chemokine receptor that is expressed on the surface of a broad range of cells including T-cells, B-cells, and macrophages, and plays an important role in immune responses. Human Immunodeficiency Virus 1 (HIV-1) uses CCR5 as a co-receptor to enter and infect immunologic cells. The antibody binds to the hydrophilic extracellular domains of the CCR5 and competitively inhibits the CCR5-mediated HIV-1 entry into the host cells. The antibody does not target viruses using CXCR4 as a receptor to enter host cells. The original drug was granted Fast Track Designation by the US FDA to treat HIV infected patients in combination with HAART, and for metastatic triple-negative breast cancer. Currently, the drug is in early clinical trials to treat COVID-19 disease.


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