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Anti-Cathepsin S Antibody

Polyclonal antibody to detect endogenous levels of Cathepsin S in human samples
Catalog #: A1618

In stock

$395.00

Product Details

Cat # +Size A1618-100
Size 100 µl
Antibody Target CTSS
Alternate Name Cathepsin S; CathepsinS; CATS_HUMAN; Ctss
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen A synthesized peptide derived from human CTSS
Accession # P25774
Gene ID 1520
Appearance Colorless liquid
Formulation In phosphate buffered saline , pH 7.4, 150mM, NaCl, 0.02% sodium azide and 50% glycerol.
Purification Affinity purified
Species Reactivity Human, Mouse, Rat
Application WB, IHC
Positive Control WB: HuvEc whole cell lysates, IHC: mouse kidney tissue
Application & Usage WB 1:1000-3000, IHC 1:200
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cathepsin S (CTSS) is a lysosomal cysteine protease of the papain family and may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. CTSS is synthesized as inactive precursor of 331 amino acids consisting of a 15-aa signal peptide, a propeptide of 99 aa, and a mature polypeptide of 217 aa. It is activated in the lysosomes by a proteolytic cleavage of the propeptide. The deduced amino acid sequence contains only one potential N-glycosylation site located in the propeptide. Compared with the abundant cathepsins B, L and H, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicate that cathepsin S generates amyloid beta-peptide from amyloidogenic fragments of amyloid precursor protein (APP) in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer’s disease and Down Syndrome.


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