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Anti-Cathepsin E Antibody

Polyclonal antibody to detect endogenous levels of Cathepsin E in human samples
Catalog #: A1709

In stock

SKU-Size Size Price Qty
A1709-30T 30 µg
$89.00
A1709-100 100 µg
$275.00
More Sizes Get Quote

Product Details

Antibody Target Cathepsin E
Alternate Name Cathepsin E form I, Cathepsin E form II, CTSE,
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Immunogen Human recombinant Cathepsin E (Cat. No. 7842)
Accession # P14091
Gene ID 1510
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation In PBS, 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% proclin
Purification Affinity purified
Species Reactivity Human
Application Western Blotting
Application & Usage Western blot: 1-4 µg
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cathepsin E (EC: 3.4.23.34) (CTSE) is an intracellular gastric aspartyl protease. It was originally identified as a cathepsin D-like acid protease. It is active in acidic conditions in a pH range from 2.5 to 5.5. In vitro experiments have identified several CTSE substrates including insulin beta chain, neurokinin, and FGF. Although the function of CTSE is not completely understood, it has been implicated in several physiological and pathological processes. CTSE is required for antigen presentation on class II MHC molecules. CTSE-deficient macrophages show abnormalities such as autophagy. Like many other cathepsins, CTSE has emerged as a therapy target for cancers, such as pancreatic ductal adenocarcinoma (PDAC). In addition to PDAC, CTSE is also overexpressed in gastric carcinomas and cervical and lung adenocarcinomas. The possible involvement of CTSE in neurodegeneration has also been reported. This protease has a specificity similar to that of pepsin A and cathepsin D. It is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. It is found in more than half of gastric cancers.


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