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Anti-Cathepsin D Antibody

Polyclonal Antibody to detect Cathepsin D in human and mouse samples
Catalog #: A1587
SKU-Size Size Price Qty
A1587-30T 30 µg
$89.00
A1587-100 100 µg
$265.00
More Sizes Get Quote

Product Details

Antibody Target Cathepsin D
Alternate Name Procathepsin D, CTSD
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Human recombinant Cathepsin D
Accession # P07339
Gene ID 1509
Appearance Colorless liquid
Formulation In PBS pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% proclin
Purification Affinity purified
Species Reactivity Human, Mouse
Application Western blot
Positive Control WB: Jurkat cell lysate, mouse muscle lysate
Application & Usage WB: 1-4 µg
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl protease with a pH optimum in the range of 3-5, and contains two N-linked oligosaccharides. Cathepsin D is synthesized as an inactive 52 kDa pro-enzyme. Activation involves the proteolytic removal of the 43 amino acid profragment and an internal cleavage to generate the two-chain form made up of 34 and 14 kDa subunits. Cathepsin D contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. In certain tumor cells, Cathepsin D is abnormally processed and is secreted in its 52 kDa precursor form. Numerous clinical studies as well as in vitro evidence sμggest that cathepsin D plays an important role in malignant transformation and may be a useful prognostic indicator for breast cancer.


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